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The final maintenance dose required to restore a euthyroid state depends on individual needs (approx. 150 ?g/d). Thyroid suppression therapy of euthyroid goiter (B). The cause of goiter (struma) is usually a dietary deficiency of iodine. Due to an increased TSH action, the thyroid is activated to raise utilization of the little iodine available to a level at which hypothyroidism is averted.
This reaction can be observed after the application of ?-sympathomimetics (naphazoline, tetrahydrozoline, xylometazoline) to the nasal mucosa. Initially, vasoconstriction reduces mucosal blood flow and, hence, capillary pressure. Fluid exuded into the interstitial space is drained through the veins, thus shrinking the nasal mucosa.

 

The contents of such illusions and hallucinations can occasionally become extremely threatening (“bad” or “bum trip”); the individual may feel provoked to turn violent or to commit suicide. Intoxication is followed by a phase of intense fatigue, feelings of shame, and humiliating emptiness. The mechanism of the psychotogenic effect remains unclear.
Capsules usually consist of an oblong casing — generally made of gelatin — that contains the drug in powder or granulated form (See. p. 9, C). In the case of the matrix-type tablet, the drug is embedded in an inert meshwork from which it is released by diffusion upon being moistened.

 

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