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Contrary to timed-release capsules , slow-release tablets have the advantage of being dividable ad libitum; thus, fractions of the dose contained within the entire tablet may be administered. This kind of retarded drug release is employed when a rapid rise in blood level of drug is undesirable.
The endothelial cells are “riveted” to each other by tight junctions or occluding zonulae (labelled Z in the electron micrograph, top left) such that no clefts, gaps, or pores remain that would permit drugs to pass unimpeded from the blood into the interstitial fluid. The blood-tissue barrier is developed differently in the various capillary beds. |
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