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Thus, the butyrophenones carry an increased risk of adverse motor reactions because they lack anticholinergic activity and, hence, are prone to upset the balance between striatal cholinergic and dopaminergic activity. Derivatives bearing a piperazine moiety (e. g. , trifluperazine, fluphenazine) have greater antipsychotic potency than do drugs containing an aliphatic side chain.
A zonula occludens or tight junction is a region in which the phospholipid membranes of two cells establish close contact and become joined via integral membrane proteins (semicircular inset, left center). |
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