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The longer-acting lorazepam is preferred as adjunct anesthetic in prolonged cardiac surgery with cardiopulmonary bypass; its amnesiogenic effect is pronounced. During sleep, the brain generates a patterned rhythmic activity that can be monitored by means of the electroencephalogram (EEG).
The CNS effects of ketamine arise, in part, from an interference with excitatory glutamatergic transmission via ligand- gated cation channels of the NMDA subtype, at which ketamine acts as a channel blocker. The non-natural excitatory amino acid N-methyl-Daspartate is a selective agonist at this receptor. |
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