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Acyclovir triphosphate is a preferred substrate of viral DNA polymerase; it inhibits enzyme activity and, following its incorporation into viral DNA, induces strand breakage because it lacks the 3’-OH group of deoxyribose that is required for the attachment of additional nucleotides.
The immediate threat results not so much from the loss of erythrocytes, i. e. , oxygen carriers, as from the reduction in volume of circulating blood. To eliminate the threat of shock, replenishment of the circulation is essential. With moderate loss of blood, administration of a plasma volume expander may be sufficient. Blood plasma consists basically of water, electrolytes, and plasma proteins. |
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