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Hypertension, fluid retention, cholestasis, benign liver tumors, nausea, chest pain, etc. may occur. Apparently there is no increased overall risk of malignant tumors. Minipill. Continuous low-dose administration of progestin alone can prevent conception. Ovulations are not suppressed regularly; the effect is then due to progestin-induced alterations in cervical and endometrial function.
Distribution in the body is determined by the ability to penetrate membranous barriers.

 

Therapeutic use aims at replacement. Mostly, vit. D is given; in liver disease calcifediol may be indicated, in renal disease calcitriol. Effectiveness, as well as rate of onset and cessation of action, increase in the order vit. D. < 25-OH-vit. D < 1,25-di-OH-vit. D.
Naltrexone may be used as an adjunct in withdrawal therapy. Buprenorphine behaves like a partial agonist/antagonist at ?-receptors. Pentazocine is an antagonist at ?-receptors and an agonist at ?-receptors (A). Both are classified as “low-ceiling” opioids (B), because neither is capable of eliciting the maximal analgesic effect obtained with morphine or meperidine.

 

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