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Dextran is a glucose polymer formed by bacteria and linked by a 1>6 instead of the typical 1>4 bond. Commercial solutions contain dextran of a mean molecular weight of 70 kDa (dextran 70) or 40 kDa (lower-molecularweight dextran, dextran 40). The chain length of single molecules, however, varies widely.
Hydroxocobalamin is an alternative, very effective antidote because its central cobalt atom binds CN- with high affinity to generate cyanocobalamin. Tolonium chloride (Toluidin Blue). Brown-colored methemoglobin, containing tri- instead of divalent iron, is incapable of carrying O2.

 

(Sulfate-)conjugated estrogens can be extracted from equine urine and are used for the prevention of postmenopausal osteoporosis and in the therapy of climacteric complaints. Because of their high polarity (sulfate, glucuronide), they would hardly appear suitable for this route of administration.
In the proximal tubules (pT), approx. 70% of the ultrafiltrate is retrieved by isoosmotic reabsorption of NaCl and water. In the thick portion of the ascending limb of Henle’s loop (HL), NaCl is absorbed unaccompanied by water. This is the prerequisite for the hairpin countercurrent mechanism that allows build-up of a very high NaCl concentration in the renal medulla.

 

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